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<?php
namespace DispatchModule\Tools;
class DbTool extends \DispatchModule\Tools\BaseTool implements \DispatchModule\Tools\ToolInterface {
protected $repository;
protected $wantedParameters;
protected $offset = 0;
protected $limit = 0;
public $label;
protected $aggregateByAccession = false;
protected $simpleSearch = false;
const RULE_EQ = 'eq';
const RULE_GT = 'gt';
const RULE_LT = 'lt';
const RULE_LIKE = 'like';
const RULE_PREFIX = 'prefix';
protected $criteria = array(
self::RULE_EQ => array(),
self::RULE_GT => array(),
self::RULE_LT => array(),
self::RULE_LIKE => array(),
self::RULE_PREFIX => array()
);
public function __construct(\Nette\DI\Container $container, ...$initialization) {
parent::__construct($container);
if (count($initialization) === 3) {
$this->label = $initialization[0];
$this->description = $initialization[1];
$this->wantedParameters = $initialization[2];
} else {
$this->label = 'Database';
$this->description = 'Union of DB tools';
$this->wantedParameters = array(
'export_accession' => array('hidden', 'Accessions'),
'start' => array('hidden', 'Start position'),
'stop' => array('hidden', 'Stop position'),
);
if (count($initialization) === 1) {
foreach ($initialization[0] as $tool) {
$this->wantedParameters = array_merge($this->wantedParameters, $tool->getWantedParameters());
}
}
}
}
public function addCriteria($name, $value) {
if (is_string($value)) {
$value = trim($value);
}
if ($this->checkReservedWord($name, $value)) {
return true;
}
if (!$this->requireParameter($name) || ($value == '' && $this->containsAttribute($name . '_array') === false)) {
return false;
}
$dbCriteria = $this->getCriteriaParam($name, $value);
if ($dbCriteria !== false) {
$this->criteria[$dbCriteria['criteria']][] = array($dbCriteria['key'] => $dbCriteria['value']);
}
return true;
}
public function execute() {
$base = $this->chooseBaseTable();
$result = $this->prepareCriteria($base . '.*, sequences:*, qualities:*, ' . $base . '.start AS dbStartPosition, ' . $base . '.stop AS dbStopPosition, ' . $base . '.start AS startPosition, ' . $base . '.stop AS stopPosition, LENGTH(sequences:sequence) AS regionLength, ' . $base . '.id AS accessionId', $base);
$result->order($base . '.stop - ' . $base . '.start DESC, ' . $base . '.accession, ' . $base . '.start, ' . $base . '.stop, ' . $base . '.id');
$return = new \DispatchModule\ResultSet;
foreach ($result as $res) {
$sequence = $this->setResults($res);
if (!$this->simpleSearch) {
$references = $this->repository->getTable('references')->select('id, title, consortium, submission_date, journal, year, volume, issue, first_page, last_page, comment, reference_location, type, number, location')->where('fk_annotation', $res['fk_annotation']);
$referenceArray = array();
$i = 0;
foreach ($references as $reference) {
$referenceArray[$i] = $reference->toArray();
$authors = $reference->related('authors');
foreach ($authors as $author) {
$referenceArray[$i]['authors'][] = $author->author['name'];
}
$applicants = $reference->related('applicants');
foreach ($applicants as $applicant) {
$referenceArray[$i]['applicants'][] = $applicant->applicant['name'];
}
$i++;
}
$sequence->loadData(array('references' => $referenceArray));
$featureArray = array();
if ($res['fk_annotation'] != '') {
$features = $this->repository->getTable('features')->select('id, name, location')->where('fk_annotation', $res['fk_annotation']);
$j = 0;
foreach ($features as $feature) {
$featureArray[$j] = $feature->toArray();
$qualifiers = $this->repository->getTable('qualifiers')->select('key, value')->where('fk_feature', $feature['id']);
foreach ($qualifiers as $qualifier) {
$featureArray[$j]['qualifiers'][$qualifier['key']] = $qualifier['value'];
}
$j++;
}
}
$sequence->loadData(array('features' => $featureArray));
$xrefArray = array();
if ($res['fk_annotation'] != '') {
$xrefs = $this->repository->getTable('xrefs')->select('*')->where('fk_annotation', $res['fk_annotation']);
foreach ($xrefs as $xref) {
$xrefArray[] = $xref->toArray();
}
}
$sequence->loadData(array('xrefs' => $xrefArray));
}
$predictions = $this->repository->getTable('predictions')->select('*')->where('fk_accession', $res['accessionId']);
$predictionArray = array();
foreach ($predictions as $prediction) {
$structure = $this->repository->getTable('structures')->where('fk_prediction', $prediction->id)->fetch()->toArray();
$wholePrediction['structure'] = $structure['structure'];
$wholePrediction['algorithm'] = $prediction->algorithm;
$wholePrediction['structure_id'] = $prediction->id;
$wholePrediction['template'] = $prediction->template;
$wholePrediction['similarity'] = $prediction->similarity;
$wholePrediction['z_score'] = $prediction->z_score;
if (!$this->simpleSearch) {
$wholePrediction['foverhangs'] = $this->getPredictionFeatures($prediction->id, 'foverhangs');
$wholePrediction['toverhangs'] = $this->getPredictionFeatures($prediction->id, 'toverhangs');
$wholePrediction['helices'] = $this->getPredictionFeatures($prediction->id, 'helices');
$wholePrediction['hairpins'] = $this->getPredictionFeatures($prediction->id, 'hairpins');
$wholePrediction['bulges'] = $this->getPredictionFeatures($prediction->id, 'bulges');
$wholePrediction['loops'] = $this->getPredictionFeatures($prediction->id, 'loops');
$wholePrediction['junctions'] = $this->getPredictionFeatures($prediction->id, 'junctions');
}
$predictionArray[] = $wholePrediction;
}
$sequence->loadData(array('predictions' => $predictionArray));
$return->addSequence($sequence);
}
return $return;
}
public function getCount($accession = null, $start = null, $stop = null) {
$base = $this->chooseBaseTable();
$result = $this->prepareCriteria('COUNT(*) AS mysize', $base);
if (isset($accession) && !empty($accession)) {
$result->where($base . '.accession', $accession);
}
if (isset($start) && !empty($start)) {
$result->where($base . '.start', $start);
}
if (isset($stop) && !empty($stop)) {
$result->where($base . '.stop', $stop);
}
$result->limit(10, 0);
$row = $result->fetch();
return $row['mysize'];
}
protected function checkReservedWord($name, $value) {
if ($name == 'offset') {
$this->offset = (int) $value;
return true;
}
if ($name == 'limit') {
$this->limit = (int) $value;
return true;
}
if ($name == 'aggregateByAccession' && $value) {
$this->aggregateByAccession = true;
return true;
}
return false;
}
protected function containsAttribute($name) {
foreach ($this->completeData as $key => $value) {
if (\Nette\Utils\Strings::endsWith($key, 'db_' . $name) && isset($value)) {
if (is_array($value)) {
foreach ($value as $val) {
if (isset($val) && $val != '') {
return substr($key, 0, -3-strlen($name));
}
}
} elseif (is_string($value) && $value != '') {
return substr($key, 0, -3-strlen($name));
}
}
}
return false;
}
protected function getCriteriaParam($name, $value) {
switch ($name) {
case'start':
$key = '%BASE_VIEW%.start';
$criteria = self::RULE_EQ;
break;
case'stop':
$key = '%BASE_VIEW%.stop';
$criteria = self::RULE_EQ;
break;
case'sequence':
$key = 'UPPER(sequences:sequence)';
$value = preg_replace('/\s+/', '', strtoupper($value));
$criteria = self::RULE_LIKE;
break;
case'name':
$key = 'LOWER(%BASE_VIEW%.name)';
$value = strtolower($value);
$criteria = self::RULE_LIKE;
break;
case'taxonomy':
$key = '%BASE_VIEW%.path_name';
$ids = explode(',', $value);
$value = array();
foreach ($ids as $id) {
$value[] = $this->getTaxonomyPath($id);
}
$criteria = self::RULE_PREFIX;
break;
case'description':
$key = 'LOWER(%BASE_VIEW%.description)';
$value = strtolower($value);
$criteria = self::RULE_LIKE;
break;
case'accession':
$key = 'UPPER(%BASE_VIEW%.accession)';
$criteria = self::RULE_PREFIX;
$prefix = $this->containsAttribute('accession_array');
if ($prefix !== false) {
$accessions = $this->completeData[$prefix . 'db_accession_array'];
if (is_array($value)) {
$accessions = array_merge($accessions, $value);
} else {
$accessions[] = $value;
}
$value = array();
foreach ($accessions as $acc) {
if (isset($acc) && $acc !== '') {
$value[] = strtoupper($acc);
}
}
} else {
if (is_string($value)) {
$value = strtoupper($value);
} elseif (is_array($value)) {
$value = array_map('strtoupper', $value);
}
}
break;
case'export_accession':
$key = 'UPPER(%BASE_VIEW%.accession)';
$criteria = self::RULE_EQ;
$lines = explode("\n", $value);
$value = array();
foreach ($lines as $line) {
$parts = explode(':', $line);
if (count($parts) === 3) {
$value[] = strtoupper($parts[0]);
}
}
break;
case'firstpublished':
$key = '%BASE_VIEW%.first_public';
$prefixDirection = $this->containsAttribute('firstpublished_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_firstpublished_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('firstpublished_array');
$prefixDirectionArray = $this->containsAttribute('firstpublished_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_firstpublished_array'], $this->completeData[$prefixDirectionArray . 'db_firstpublished_direction_array']);
}
break;
case'sequence_quality':
$key = 'qualities:sequence_quality';
$criteria = self::RULE_GT;
break;
case'region_length':
$key = '%BASE_VIEW%.region_length';
$prefixDirection = $this->containsAttribute('region_length_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_region_length_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('region_length_array');
$prefixDirectionArray = $this->containsAttribute('region_length_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_region_length_array'], $this->completeData[$prefixDirectionArray . 'db_region_length_direction_array']);
}
break;
case'molecule_type':
$key = '%BASE_VIEW%.dataset';
$criteria = self::RULE_EQ;
$prefix = $this->containsAttribute('molecule_type_array');
if ($prefix !== false) {
$moleculetypes = $this->completeData[$prefix . 'db_molecule_type_array'];
$moleculetypes[] = $value;
$value = $moleculetypes;
}
break;
case'ambiguities':
$key = 'qualities:ambiguities';
$prefixDirection = $this->containsAttribute('ambiguities_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_ambiguities_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('ambiguities_array');
$prefixDirectionArray = $this->containsAttribute('ambiguities_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_ambiguities_array'], $this->completeData[$prefixDirectionArray . 'db_ambiguities_direction_array']);
}
break;
case'homopolymers':
$key = 'qualities:homopolymers';
$prefixDirection = $this->containsAttribute('homopolymers_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_homopolymers_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('homopolymers_array');
$prefixDirectionArray = $this->containsAttribute('homopolymers_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_homopolymers_array'], $this->completeData[$prefixDirectionArray . 'db_homopolymers_direction_array']);
}
break;
case'base_pair_score':
$key = 'qualities:base_pair_score';
$prefixDirection = $this->containsAttribute('base_pair_score_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_base_pair_score_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('base_pair_score_array');
$prefixDirectionArray = $this->containsAttribute('base_pair_score_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_base_pair_score_array'], $this->completeData[$prefixDirectionArray . 'db_base_pair_score_direction_array']);
}
break;
case'aligned_bases':
$key = 'qualities:aligned_bases';
$prefixDirection = $this->containsAttribute('aligned_bases_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_aligned_bases_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('aligned_bases_array');
$prefixDirectionArray = $this->containsAttribute('aligned_bases_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_aligned_bases_array'], $this->completeData[$prefixDirectionArray . 'db_aligned_bases_direction_array']);
}
break;
case'alignment_quality':
$key = 'qualities:alignment_quality';
$prefixDirection = $this->containsAttribute('alignment_quality_direction');
if ($prefixDirection !== false && $this->completeData[$prefixDirection . 'db_alignment_quality_direction'] == 'gt') {
$criteria = self::RULE_GT;
} else {
$criteria = self::RULE_LT;
}
$prefixArray = $this->containsAttribute('alignment_quality_array');
$prefixDirectionArray = $this->containsAttribute('alignment_quality_direction_array');
if ($prefixArray !== false && $prefixDirectionArray !== false && $prefixArray === $prefixDirectionArray) {
$this->defineMultipliedRules($key, $this->completeData[$prefixArray . 'db_alignment_quality_array'], $this->completeData[$prefixDirectionArray . 'db_alignment_quality_direction_array']);
}
break;
default:
return false;
}
if ($value == '' || (is_array($value) && empty($value))) {
return false;
}
return array('criteria' => $criteria, 'key' => $key, 'value' => $value);
}
protected function prepareCriteria($select, $base = 'vw_acc_ann_tax') {
$query = $this->repository->getTable($base)->select($select);
foreach ($this->criteria[self::RULE_EQ] as $eqRule) {
foreach ($eqRule as $key => $val) {
$query->where($this->prepareKey($key, $base), $val);
}
}
foreach ($this->criteria[self::RULE_GT] as $gtRule) {
foreach ($gtRule as $key => $val) {
$query->where($this->prepareKey($key, $base) . ' > ?', $val);
}
}
foreach ($this->criteria[self::RULE_LT] as $ltRule) {
foreach ($ltRule as $key => $val) {
$query->where($this->prepareKey($key, $base) . ' < ?', $val);
}
}
foreach ($this->criteria[self::RULE_LIKE] as $gtRule) {
foreach ($gtRule as $key => $val) {
$query->where($this->prepareKey($key, $base) . ' LIKE ?', '%' . $val . '%');
}
}
foreach ($this->criteria[self::RULE_PREFIX] as $prefRule) {
foreach ($prefRule as $key => $val) {
$key = $this->prepareKey($key, $base);
if (is_array($val)) {
$condition = '';
foreach ($val as $v) {
$condition .= ($condition == '') ? $key : ' OR ' . $key;
$condition .= ' LIKE ?';
}
array_walk($val, function(&$item) {
$item = $item . '%';
});
if (count($val) == 1) {
$val = $val[0];
}
$query->where($condition, $val);
} else {
$query->where($key . ' LIKE ?', $val . '%');
}
}
}
if ($this->limit != 0) {
$query->limit($this->limit, $this->offset);
}
return $query;
}
private function setResults(\Nette\Database\Table\ActiveRow $tableData) {
$sequence = new \DispatchModule\Sequence;
$data = array();
foreach ($tableData as $name => $value) {
$data[$this->toCamelCase($name)] = $value;
}
$sequence->loadData($data);
return $sequence;
}
protected function prepareKey($key, $base) {
return str_replace('%BASE_VIEW%', $base, $key);
}
protected function chooseBaseTable() {
$base = 'vw_acc_ann_tax';
return $base;
}
public function getLabel() {
return $this->label;
}
private function toCamelCase($name) {
$nameArray = explode('_', $name);
$result = '';
for ($i = 0; $i < count($nameArray); $i++) {
if ($i > 0) {
$nameArray[$i] = \Nette\Utils\Strings::firstUpper($nameArray[$i]);
}
$result .= $nameArray[$i];
}
return $result;
}
protected function getPredictionFeatures($predictionId, $type) {
$array = array();
if (in_array($type, array('bulges', 'foverhangs', 'hairpins', 'helices', 'junctions', 'loops', 'toverhangs', 'pseudoknots', 'unconserveds', 'unmeasureds', 'tangleds'))) {
$fkName = 'fk_' . substr($type, 0, -1);
$query = 'SELECT T.id, TP.start, TP.stop FROM ' . $type . ' AS T '
. 'INNER JOIN ' . $type . '_positions AS TP ON TP.' . $fkName . ' = T.id '
. 'WHERE fk_prediction = ? ORDER BY T.id, TP.start';
$characteristics = $this->repository->getConnection()->queryArgs($query, array($predictionId));
foreach ($characteristics as $characteristic) {
$array[] = array($characteristic['start'], $characteristic['stop'], $characteristic['id']);
}
}
return $array;
}
protected function defineMultipliedRules($key, $allValues, $allDirections) {
if (isset($allValues[0], $allDirections[0]) && $allValues[0] != '') {
if ($allDirections[0] == 'gt') {
$this->criteria[self::RULE_GT][] = array($key => $allValues[0]);
} else {
$this->criteria[self::RULE_LT][] = array($key => $allValues[0]);
}
}
}
protected function getTaxonomyPath($value) {
$row = $this->repository->getTable('taxonomy')->where('id', $value)->fetch();
if ($row) {
$result = $row['path_name'];
} else {
$result = '';
}
return $result;
}
protected function lastTaxonomySelected($value) {
$i = 0;
while (isset($value[$i]) && $value[$i] != '') {
$i++;
}
return $value[$i - 1];
}
public function getNameValues($organismName) {
$storage = new \Nette\Caching\Storages\FileStorage('../temp');
$cache = new \Nette\Caching\Cache($storage);
$uid = 'getNameValues' . md5($organismName);
$result = $cache->load($uid);
if ($result === NULL) {
$result = array();
foreach ($this->repository->getTable('vw_acc_ann_tax')
->select('DISTINCT name')
->where('LOWER(name) LIKE ?', '%' . strtolower($organismName) . '%')
->order('name')
->limit(10)
as $row) {
$result[] = $row['name'];
}
$cache->save($uid, $result, array(
\Nette\Caching\Cache::EXPIRE => LONG_CACHE_TIME,
));
}
return $result;
}
public function setSimpleSearch($val) {
$this->simpleSearch = $val;
}
}